Ethylene chlorohydrin




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2-chloroethanol Animal Chronic Toxicity

Time:2015/9/24 8:30:28

2-chloroethanol Animal Chronic Toxicity (Repeated doses for period exceeding 1 Year)

The results of oral and parenteral administration of ethylene chlorohy summarized In references 40 hd 44-47. No chronic systemic toxic dfecb or carcinogenic effects were detected In mice and rats.

2-chloroethanol Mulagenicitg

Two studies have been reported in which increaseg in chromosome aberrations in rat bone marrow cells were induced after exposure to 2-chloroethanol (Isakova. O. K., et al., Ref. 32 and Semenova, V. N., et 8I.,Ref. 33). Rosenkranz and W'lodlro~~bt(Ref. 341 found a dose-related increase in mutation rate in strains TA1530 and TA1535 of Sulmonella, but na fncnase in strain TA1538, which fndic8tes that ethylene chlorohydrh Induces baSepair substitutions, but not frameshift mutations. Data from studies by Rannug et al. (Ref. 79) show ethylene chlorohydrfn to be a weaker mutagen than ethylene oxide in causing mu& tions in SdmoneUa TA1535.

2-chloroethanol Te?u&venicfty and FetotaeZcftu

Verrett (Ref. 80) tested 2-chloroethanol for teratogenic and fetotoxic effects in the developing chick embryo by injecting 5. 12.5, 25, and 50mg/@ in the alr sac of 4-day old embryos.

This resulted in a dose-related increase in defective embryos. A later study (Courtney and Andrews. Ref.81) in CD-1 mice failed to produce malformations when ethylene chlorohydrln was administered orally or by inhalation.