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2-chloroethanol derivation of aegl values

Time:2015/9/24 7:50:53

Derivation of AEGL-1 Values for 2-chloroethanol


Due to insufficient data regarding AEGL-1 severity effects and the overall exposure-response relationship for 2-chloroethanol vapor exposure, AEGL-1 values are not recommended.


Absence of AEGL-1 values does not imply that exposures below the AEGL-2 levels are without effect.


Derivation of AEGL-2 Values for Ethylene Chloride


Due to insufficient data on AEGL-2 severity effects, the AEGL-2 values were estimated as one third of the AEGL-3 values as per guidance in NRC (2001). The lethality data in rats, mice,and guinea pigs indicated a steep exposure-response relationship.


10-minute AEGL-2 21 ppm/3 = 7.0 ppm


30-minute AEGL-2 15 ppm/3 = 5.0 ppm


1-hour AEGL-2 12 ppm/3 = 4.0 ppm


4-hour AEGL-2 4.7 ppm/3 = 1.6 ppm


8-hour AEGL-2 2.3 ppm/3 = 0.77 ppm


Derivation of AEGL-3 Values for 2-chloroethanol


Key study:       Goldblatt, M.W. 1944. Toxic effects of 2-chloroethanol. Part II.

                 Experimental. Br. J. Ind. Med. 1:213-223.


Critical effect: A 120-minute nonlethal exposure at 280 ppm in mice was used as an

                 estimated lethality threshold. A 120-minute exposure to 1090 ppm resulted in 100% lethality.


Time scaling:    Cn 10 x t = k, where n = 1 or 3 (NRC, 2001)


Uncertainty factors: Total uncertainty factor adjustment is 30.


Interspecies: 3; Based upon the differences in the lethal response between

              the rats and mice, an interspecies uncertainty factor of 3 was considered

              appropriate. Guinea pigs were less sensitive than either rats or mice.

              Comparison of AEGL-3 values to an exposure resulting in a human

              lethality (300 ppm for 2 hours) shows the AEGL-3 values to be

               sufficiently protective.


Intraspecies: 10; 2-chloroethanol does not appear to be a direct-

              contact irritant and death in animals does not appear to be a function of

              damaged respiratory tract epithelial tissue. In the absence of data

              regarding the mode of action of 2-chloroethanol toxicity and

              because of the small numbers of animals used in the reported studies, an

              intraspecies uncertainty of 10 is retained. Sensitive populations could not be identified.


Modifying Factor: None applied


Calculation: (280 ppm)1 29 x 120 min = 33,600 ppm · min (280 ppm)3x 120 min = 2,634,240,000 ppm3 30 · min

 

10-minute AEGL-3 C3 33 x 10 min = 2,634,240,000 ppm · min

              C = 641 ppm

              C = 641 ppm/30 = 21 ppm

30-minute AEGL-3 C3 x 30 min = 2,634,240,000 ppm3 38 · min

              C = 445 ppm

              C = 445 ppm/30 = 14.8 ppm (rounded to 15 ppm)