Ethylene chlorohydrin




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2-chloroethanol have been studied in lowtemperature matrices

Time:2015/12/3 6:56:52

Carcinogenic activity of ethylene oxide and its reaction products 2-chloroethanol, 2-bromoethanol, ethylene glycol and diethylene glycol
ABSTRACT Ethylene glycol and diethylene glycol were each administered once weekly subcutaneously to groups of 100 female NMRI mice at 3 dosages (30; 10 und 3 mg single dose per mouse). Tricaprylin was used as solvent. The mean total dosage per mouse was 2110.5; 707.0 and 196.2 mg for ethylene glycol and 2029.8; 671.7 and 213.3 mg for diethylene glycol. Neither ethylene glycol nor diethylene glycol induced tumors at the injection site or away from the point of administration.
Infrared-induced conformational isomerization of 2-chloroethanol and 2-chloroethylamine in low-temperature matrices
The infrared spectra of 2-chloroethanol and 2-chloroethylamine have been studied in lowtemperature matrices. In the case of, 2-chloroethanol, the spectral changes in the C-Cl stretching and 0-H _stretching regions indicated that the gauche to trans isomerization around the C-C bond occurred by infrared irradiation (Fig.1). These spectral changes occurred in the argon matrix but not in the nitrogen matrix. When the nozzle temperature was elevated from room temperature to 750 K, the populations of the trans conform ers increa, sed in both argon (Fig.2) and nitrogen (Fig.3) matrices. However, the relative intensities of the resultant trans conformers in the nitrogen matrix were different from thos e in the argon matrix.In the case of 2-chloroethylamine, the spectral changes in the NH2 wagging and C-Cl stretching regions indicated the gauche to trans isomerization around. the C-C bond in argon matrices (Fig.5 and Fig.6). The spectrum of the resultant trans form changed by elevating the matrix temperature from 20 to 28 K. The rate of this transformation strongly depended on the matrix temperature (Fig.7). The same result was obtained in the deuterioamino species, ClCH2CH2NHD and ClCH2CH2ND2