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Ethylene chlorohydrin

2-chloroethanol

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Chlorohydrin data analysis for aegl-2

Time:2015/9/24 7:18:43


Chlorohydrin Human Data Relevant to AEGL-2


There are no quantitative human data with which to develop AEGL-2 values for ethylene chlorohydrin. Although nonlethal exposures reportedly resulted in a wide range of effects

(Goldblatt and Chiesman, 1944; Bush et al., 1949), either exposure concentration data or exposure duration data (or both) are lacking.


Chlorohydrin  Animal Data Relevant to AEGL-2


Animal data appropriate for AEGL-2 derivation are deficient in characterization of the nonlethal effects and do not provide an exposure-response relationship.


Chlorohydrin Derivation of AEGL-2 Values


Exposure-response data for toxic effects consistent with AEGL-2 severity are lacking.Case reports in humans lack exposure terms and animal toxicity data focus on only the lethal

response with most experimental results showing near 100% lethality. In experiments with less than 100% lethality, no information is provided regarding the precise nature or severity of the effects or if any effects were observed.


Following the guidelines in NRC (2001), the AEGL-2 values for ethylene chlorohydrin have been estimated as one third of the AEGL-3 values. Data in mice (Goldblatt, 1944) showed 

ETHYLENE CHLOROHYDRIN (2-CHLOROETHANOL) Page 17 of 37 INTERIM 05/2008

there to be less than a four-fold difference between a nonlethal response (280 ppm for 120minutes) and 100% lethality (1,090 ppm for 120 minutes) which implies a steep exposure-

response relationship. The AEGL-2 values for ethylene chlorohydrin are shown in Table 7.