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Ethylene chlorohydrin

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Ethylene chlorohydrin Nonlethal Toxicity

Time:2015/9/24 6:58:20

An odor threshold of 0.4 ppm has been reported (Semenova et al., 1980). Data are unavailable with which to calculate an Acute Level of Odor Awareness (LOA). ETHYLENE CHLOROHYDRIN (2-CHLOROETHANOL) Page 10 of 37 INTERIM 05/2008 Several nonfatal case reports of exposure to ethylene chlorohydrin vapor were summarized by Goldblatt and Cheisman (1944). There were no exposure data for these cases and there was likely concurrent exposure to ethylene dichloride. A qualitative summary of signs and symptoms by organ system was provided: digestive system (nausea, epigastric pain,vomiting); cardiovascular system (shock, depressed circulation); nervous system (headache,giddiness, incoordination, confusion, mild narcotic effects); respiratory system (cough, rhonchi);skin (erythema on arms and trunk in severe cases).


In addition to the previously fatality noted in Section 2.1, Bush et al. (1949) also reported several nonfatal exposures to ethylene chlorohydrin (400-500 ppm) but no exposure duration was provided although it was noted that this level was likely constant for up to 140 hours with a peak concentration of 3300 ppm being attained at about 4 hours. The signs and symptoms included nausea, vomiting, and irritation of the eyes, nose and lungs.


Developmental/Reproductive Effects Data on the developmental/reproductive toxicity of ethylene chlorohydrin in humans were not available.


Ethylene chlorohydrin Genotoxicity 


No information regarding the genotoxicity of ethylene chlorohydrin in humans was available.


Ethylene chlorohydrin Carcinogenicity Greenberg et al. (1990) reported an increased risk of mortality from pancreatic cancer and leukemia in workers at a Union Carbide plant in which ethylene chlorohydrin was manufactured. In a 10-year follow-up on 278 male workers at this plant, Benson and Teta (1993) reported excess deaths from pancreatic cancer (8 observed vs 1.6 expected, SMR=492 with 95% c.i. of 158-1140) and lymphopoietic and hematopoietic cancers (8 observed vs 2.7 expected; SMR=294 with 95% c.i. of 127-580). Olsen et al. (1997) found no increased risk for these cancers in workers at Dow Chemical facilities.


Ethylene chlorohydrin Summary


Human data with which to develop AEGL values are not available. Only limited qualitative information is available regarding the inhalation toxicity of ethylene chlorohydrin in humans. The available reports lack exposure terms and involve concurrent exposure to other chemicals. Case reports failed to provide definitive information regarding target organs or cause of death.