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Ethylene chlorohydrin

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Ethylene chlorohydrin Nonlethal Toxicity

Time:2015/9/24 7:09:30

Ethylene chlorohydrin Rats


A 1-hour exposure to 4 ppm was not lethal to rats (Ambrose, 1950). Goldblatt (1944) reported that a single 15-minute exposure of rats (gender and strain not specified) to ethylene chlorohydrin (0.003 g/L; equivalent to ~840 ppm) was not lethal. Goldblatt noted that exposed rats exhibited signs of caused discomfort, eye closure, and nasal irritation but it was unclear as to whether or not these observations pertained to all rats or just those more severely affected.


Ethylene chlorohydrin Mice


A 120-minute exposure of mice (gender and strain not specified) to 0.001 g ethylene chlorohydrin/L (~280 ppm) was not lethal (Goldblatt, 1944).


Ethylene chlorohydrin Guinea pigs


A single 30-minute exposure to 0.003 g/L (~840 ppm) or a 55-minute exposure to 0.005g/L (~1406 ppm) was not lethal to guinea pig (only 1 animal/ exposure) (Goldblatt, 1944).


Ethylene chlorohydrin Cats


Goldblatt (1944) reported that cats (no details provided regarding gender, breed, number of animals, etc.) inhaling ethylene chlorohydrin at concentrations of 10-15 mg/L (2,800-4,200 21 ppm) for several hours showed no effects on blood pressure and no signs of respiratory disturbances regardless of whether the exposure was via a tracheal cannula or through the nasal passages.


Ethylene chlorohydrin Rabbits


Similar to the findings in cats, Goldblatt (1944) also reported that inhalation of ethylene chlorohydrin (same exposures as for cats; see Section 3.2.4) by rabbits (no specifics available regarding gender, strain, age, etc.) had no apparent effect on blood pressure or respiration.


Summary of Nonlethal Toxicity in Animals


Available data do not precisely characterize the dose-response relationship for nonlethal effects of exposure to ethylene chlorohydrin vapor. Most studies were conducted as lethality assays and, although identifying some exposures as nonlethal, do not provide detailed information on the nature or severity of the effects (if any) that occurred at these exposures.Generally, the exposure-response relationship is poorly defined.