Ethylene chlorohydrin




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Ethylene chlorohydrin acute lethality

Time:2015/9/24 6:51:51

Goldblatt and Chiesman (1944) described two fatal cases originally reported by Koelsch(1927) involving acute exposure to ethylene chlorohydrin. Both cases involved individuals with comprised health and dermal exposure. Exposure durations were 2.5 hours or more. Signs of toxicity included nausea and vomiting, and signs of narcosis. The actual cause of death was uncertain.

Dierker and Brown (1944) reported a fatal case in which a man was exposed for 2 hours to ethylene chlorohydrin and petroleum solvents during a cleaning operation. A post exposure estimated of the ethylene chlorohydrin concentration was estimated by resuming the cleaning operation and concentrations of ethylene chlorohydrin measured by staff with respiratory protection at the breathing level. The petroleum solvent level was 150-400 ppm while the average ethylene chlorohydrin level was estimated at 305 ppm.

Industrial exposure to ethylene chlorohydrin (300-500 ppm estimated) for a nonspecified duration resulted in one death (Bush et al., 1949). Autopsy findings revealed severe liver and brain damage as well as involvement of other organs.