Ethylene chlorohydrin




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chlorohydrin and related compounds on the reproductive organs

Time:2015/12/4 2:30:35

Effects of chlorohydrin and related compounds on the reproductive organs and fertility of the male rat

 The antifertility effects and histopathological changes in the reproductive tract of male rats following administration of α chlorohydrin, α bromohydrin, epi chlorohydrin and glycidol were compared. Contrary to earlier reports, α bromohydrin induced bilateral spermatoceles and permanent sterility in rats but did not produce the functional epididymal sterilizing effect of α chlorohydrin. Glycidol reproduced the primary sterilizing effect of α chlorohydrin but not the lesions in the proximal caput epididymidis. Epi chlorohydrin showed activities resembling those of α chlorohydrin. The primary lesion in the proximal caput epididymidis was seen specifically to involve the 'conus' and adjacent regions with sloughing of the epithelium. This may impair the secretory absorptive function of this region with ensuing severe damage to the thin walled ductuli efferentes. Except where granulomata were formed, restoration of the epithelium occurred. The apical region of the proximal caput remained undamaged throughout.
 Distribution of (carbon-14)alpha-chlorohydrin in mice and rats
 The distribution of (carbon-14)alpha-chlorohydrin in mice and rats was investigated. 6 albino male mice and 6 albino male rats received an intravenous injection and after survival times of 5, 20, and 60 minutes, 4 and 24 hours, and 4 days, the animals were sacrificed. Resulting autoradiograms revealed a marked difference in the distribution of radioactivity in the epididymis of mice and rats. 24 hours postinjection the radioactivity in the epididymis of the mouse only slightly exceeded that in blood while in the rat the radioactivity in the cauda epididymidis was among the highest in the body. This was more pronounced 4 days postinjection. No accumulation of carbon 14 was seen in the accessory sexual glands. There were high amounts of carbon 14 in the liver and bile of both species shortly after injection. Both species revealed high amounts of radioactivity in the sebaceous glands 24 hours and 4 days postinjection. Radioactivity was also high in the mouse thymus and Harder's gland.