Chlorohydrin

Ethylene chlorohydrin

2-chloroethanol

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ethylene chlorohydrin is carried out in rats

Time:2015/12/18 6:10:22

Short-term toxicity of ethylene chlorohydrin (ECH) in rats, dogs and monkeys

Oral dosage studies on ethylene chlorohydrin (ECH) were carried out in rats, dogs and monkeys of both sexes for periods of at least 90 days. The responses of the animals to three graded dosage levels of ECH were compared with those of controls fed unsupplemented rations appropriate for the respective species. Doses were administered to rats by intubation, to dogs in their diet, and to monkeys by syringe. All dose mixtures were freshly prepared each day. Behaviour, growth, survival, blood parameters and urine analyses were recorded. Terminally, gross and microscopic examinations were made of organs and tissues and the major organs were weighed.In the rats, no adverse findings were seen with dose levels of 30 and 45 mg ECH/kg body weight/day, but with 67·5 mg/kg, growth was depressed in both sexes and mortality was high. In dogs, ingestion of the ECH diet was followed by severe emesis, which limited the highest intake that could be retained to approximately 18–20mg/kg/day regardless of dietary level. The dogs showed some variations in haemoglobin and haematocrit readings, but these were not correlated with dosage. The treated dogs did not grow, but all survived. The monkeys also failed to increase in weight at treatment levels up to 62·5 mg/kg, but showed no noteworthy differences from the controls. Gross and histopathological examinations disclosed no consistent dose-related abnormalities in any of the species.

Ocular toxicity of ethylene chlorohydrin and ethylene glycol in rabbit eyes

Toxicity and irritation of ethylene chlorohydrin and ethylene glycol were assessed in rabbit eyes following multiple topical or multiple intraocular (anterior chamber) administrations. Ethylene glycol was nontoxic and nonirritating at 0.4% concentration following topical and intraocular administration. Ocular toxicity at higher test concentrations consisted of conjunctival redness, chemosis, flare, and iritis. Ethylene chlorohydrin was nontoxic and nonirritating at 1.0% and 0.5% concentrations following topical and intraocular administration, respectively. Ocular toxicity at higher test concentrations consisted of conjunctival redness, chemosis, discharge, flare, iritis, pannus, transient corneal opacity (topical route), nontransient corneal opacity (intraocular route), lens capsule rupture, and opaque lens.