2-氯乙醇 CAS NO 107-07-3

　　2-Chloroethanol CAS Numbers 107-07-3

　　2-Chloroethanol with CAS no 107-07-3 under the brand names Mallak ECH.We manufacture and export this product used in building block in the production of active pharmaceutical ingredients(API),biocides and plasticizers.Its similar name are 2-Choro-1-ethanol;Methanol-methyl chloride;1-Choro-2-hydroxyethane.

　　Appeatance:Clear, colorless liquid

　　Odour:Sweet pleasant

　　Product Name:2-Chloroethanol

　　CAS: 107-07-3

　　Formula: C2-H5-Cl-O

　　Purity:99.5%

　　Impurity:0.50% max

　　Moisture:0.50%

　　Density:1.202-1.206g/ml at 20℃(lit)

　　Boiling Point:128-130℃

　　Flash Point:57.26℃

　　Synonyms/Common Names

　　Ethanol, 2-chloro-Ethylene chlorohydrin

　　Short-Term Toxicity

　　14-Day (Topical Application) (C50135) Completed

　　Rats: F344/N; Mice: Swiss

　　13-Week (Topical Application) (C50135) Completed

　　Rats: F344/N; Mice: Swiss

　　Dose: R: 0, 62, 1000, M: 0, 50, 450 MG/KG/10 PER GROUP.

　　Long-Term Carcinogenicity

　　2-Year (Topical Application) (C50135) Completed

　　TR-275 (NIH Number: 86-2531) (Peer Review Approval 07/27/1984A )

　　Toxicology and Carcinogenesis Studies of 2-Chloroethanol (Ethylene Chlorohydrin) (CASRN 107-07-3) in F344/N Rats and Swiss CD-1 Mice (Dermal Studies)

　　Rats: F344/N; Mice: Swiss

　　Carcinogenesis Results

　　Male Rats No Evidence

　　Female Rats No Evidence

　　Male Mice No Evidence

　　Female Mice No Evidence

　　Dose: R: 0, 50, 100, M: 0, 7.5, 15 MG/KG/50 PER GROUP.

　　Genetic Toxicology

　　Chromosome Aberrations (208472) Completed

　　Mice

　　Negative

　　Drosophila (595891) Completed

　　Citation: Valencia, R., Mason, J.M., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: III. Results of 48 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 325-348

　　Reciprocal Translocation/Sex-Linked Recessive Lethal Negative

　　In Vitro Cytogenetics (CA/SCE) (165108) Completed

　　Citation: Ivett, J.L., Brown, B.M., Rodgers, C., Anderson, B.E., Resnick, M.A., Zeiger, E. Chromosomal aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro IV: Results for 15 chemicals Environ. Molec. Mutagen. Vol. 14 (1989) 165-187

　　Sister Chromatid Exchange Positive

　　Chromosome Aberrations Positive

　　Micronucleus (666681) Completed

　　Citation: Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179

　　Mice: B6C3F1

　　Male Negative

　　Mouse Lymphoma (951597) Completed

　　Citation: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ. Molec. Mutagen. Vol. 12 (1988) 85-154

　　Mice

　　Positive

　　Salmonella (051370) Completed

　　Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142

　　Positive

　　Salmonella (052370) Completed

　　Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142

　　Positive

　　Salmonella (552370) Completed

　　Citation: Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142

　　Positive

　　Sister Chromatid Exchanges (208472) Completed

　　Mice

　　Sister Chromatid Negative

　　Sister Chromatid Exchanges (495716) Completed

　　Mice

　　Sister Chromatid Negative

　　Organ Systems Toxicity

　　4 to 6 GD Conventional Teratology (Intravenous) (TER84070A) Completed

　　Female Mice: Swiss CD-1

　　Mice Maternal Positive

　　Mice Fetal Positive

　　Dose: 60, 120 MG/KG/DAY.

　　6 to 8 GD Conventional Teratology (Intravenous) (TER84070B) Completed

　　Female Mice: Swiss CD-1

　　Mice Maternal Positive

　　Mice Fetal Positive

　　Dose: 60, 120 MG/KG/DAY.

　　8 to 10 GD Conventional Teratology (Intravenous) (TER84070C) Completed

　　Female Mice: Swiss CD-1

　　Mice Maternal Positive

　　Mice Fetal Positive

　　Dose: 60, 120 MG/KG/DAY.

　　10 to 12 GD Conventional Teratology (Intravenous) (TER84070D) Completed

　　Female Mice: Swiss

　　Mice Maternal Positive

　　Mice Fetal Positive

　　Dose: 60, 120 MG/KG/DAY.

　　6 to 14 GD Conventional Teratology (Intravenous) (TER84071) Completed

　　Female Rabbits: New Zealand White

　　Rabbits Maternal Negative

　　Rabbits Fetal Negative

　　Dose: 9, 18, 36 MG/KG/D.

　　Toxic Effects and Modes of Action

　　2-Chloroethanol produces both local and systemic toxic effects. Systemic toxicity can develop after inhalative or oral intake and also after percutaneous absorption. The main symptoms involve central nervous system depression; in mild cases the symptoms are stupor, dizziness, headaches, nausea and vomiting [1- 4]; larger doses can lead to confusion, unconsciousness, convulsions, reduced blood pressure and central paralysis [1-3, 5]. In addition, particularly after higher doses, damage to the liver, kidneys, lungs and cardiocirculatory system can develop; pulmonary oedema, arrhythmia, proteinuria, haematuria and reduced blood pressure have been described [2, 3, 6]. After repeated intake, the substance tends to accumulate [1, 4, 6, 7]. On the intact skin, 2-chloroethanol causes weak local irritation [8, 9]; sensitization tests with the substance have yielded negative results.

　　Inhalation toxicity of 2-chloroethanol

　　In another study [30], a single exposure to as little as 7.5 ml/m3 for 1 hour was lethal for rats; inhalation of 2 ml/m3 resulted in severe pathological changes and was also lethal after repeated exposures. Very high inhalation toxicity of 2-chloroethanol was also found in a study [32] in which exposure of rats to a concentration of 32 ml/m3 for 4 hours killed some of the animals.

　　Reduced growth which could not be accounted for entirely by reduced food consumption was seen in studies in which groups of 5 young rats were given 2-chloroethanol concentrations of 0.12 or 0.16 % in the diet for 220 days [30]. Concentrations of 0.24% and more caused a dose-dependent increase in mortality; 0.08% 2-chloroethanol in the diet (34.6 mg/kg body weight and day) did not inhibit the growth of rats in these studies [30]. In 90-day feeding studies with rats, dogs and monkeys, a no effect level for 2-chloroethanol of about 45 mg per kg body weight was determined.

n  Company Overview  

  Wuxi Ginkgo Plastic Industry Co.,Ltd. was founded in 1985, mainly engaged in 

  2-chloroethanol and phenolic resins, now it is the major manufacturer of industrial 

  grade and pharmaceutical grade 2-chloroethanol. It is located in Heqiao Town, 

  Yixing City and Jiangsu Province, where is known as a tourist attraction, pottery 

  capital and the hometown of professor. The company always attach importance 

  to technological innovation and talent cohesion, with many domestic famous  

  universities maintaining cooperation in scientific research, thereby a highly qualified 

  technical team is cultivated. It achieves ISO 9001, ISO 14001 and OHSAS 18001,

  and is repeatedly rated as "Advanced Units For Safe Production" and "Clean Factory".

n  Company Concept

  Over the years, the company has been adhering to the concept of "safety in 

  production, environmental protection priority, people-oriented", increasing and 

  improving safety facilities, optimizing environmental governance, reducing pollutant 

  emissions, protecting employees' occupational health and safety, and protecting the 

  environment.

n  Production Capacity

  Due to the efforts of all staff, the company has a workshop of 1500 square meters 

  and an experimental center of 500 square meters. The production process and 

  quality control are stable and reliable, and product quality has reached international 

  standards, which can meet the requirements of users at home and abroad.