2-chloroethanol Effect on hepatic microsomal enzymes

Effect of 2-chloroethanol on hepatic microsomal enzymes in the rat

The effect of 2-chloroethanol on the activities of hepatic microsomal enzymes in the rat has been studied. A significant reduction in activities of drug-metabolizing enzymes (aminopyrine N-demethylase, coumarin 3-hydroxylase) and a marked decrease of glucose 6-phosphatase were seen in both sexes given dose levels of 20 mg/kg sc daily for 7 days. Inosine diphosphatase activity remained unaltered. In male rats given 3 or 10 mg/kg, a trend in the inhibition of drug metabolism was found. A single dose of 50 mg/kg caused no apparent change in the activities of the enzymes measured.

Intermolecular interactions in binary mixtures of 2-Chloroethanol with 2-Dimethylaminoethanol and 2-Diethylaminoethanol at different temperatures

The ultrasonic velocity () and density () of binary mixtures of 2-Chloroethanol (2-CletOH) with 2-Dimethylaminoethanol (DMAE) and 2-Diethylaminoethanol (DEAE) have been measured over the entire concentration range at temperatures 293.15, 303.15 and 313.15 K. The ultrasonic velocity and density data are used to estimate adiabatic compressibility (), intermolecular free length (), molar sound velocity (), molar compressibility () and specific acoustic impedance () along with excess values of ultrasonic velocity (), adiabatic compressibility (), intermolecular free length (), acoustic impedance () and molar volume (). The infrared spectra of both of the systems, 2-CletOH + DMAE and 2-CletOH + DEAE, have also been recorded at room temperature (298.15 K). The observed variations of these parameters, with concentration and temperature, are discussed in terms of the intermolecular interactions