Ethylene chlorohydrin News
Ethylene chlorohydrin
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- Cas No.:107-07-3
- Appearance:Colorless liquid
- Molecular Formula:C2H5ClO
- ProductionCapacity:
- Inquiry
Detailed information
Ethylene chlorohydrin Chemistry
Formula C2H5ClO
Molecular weight 80.52
CAS No 107-07-3
Appearance Colorless liquid
Assay (GC, area%) ≥ 99%
Acid value(Calculation based HCl) ≤ 0.05%
Water (according to Karl Fischer) ≤ 0.10%
Density (at 20°C, g/ml) 1.200 - 1.203
Ethylene chlorohydrin Uses
ethylene chlorohydrin is a building block in the production of pharmaceuticals, biocides and plasticizers. It is also used for manufacture of thiodiglycol. It is a solvent for cellulose acetate and ethyl cellulose, textile printing dyes, extraction of pine lignin, in dewaxing, refining of rosin, and the cleaning of machines.
Several dyes are prepared by the alkylation of aniline derivatives with chloroethanol.
Ethylene Chlorohydrin can affect you when breathed in and by passing through your skin.
Ethylene Chlorohydrin may cause reproductive damage.Handle with extreme caution.
Contact can cause skin and eye irritation.
Breathing Ethylene Chlorohydrin can irritate the nose and throat causing coughing and wheezing.
Breathing Ethylene Chlorohydrin can irritate the lungs causing coughing and/or shortness of breath. Higher exposures may cause a build-up of fluid in the lungs
(pulmonary edema), a medical emergency, with severe shortness of breath.
Ethylene Chlorohydrin can cause nausea, vomiting and abdominal pain.
Ethylene Chlorohydrin can affect concentration and memory and can cause headache. dizziness.lightheadedness. confusion. seizures (fits) and passing out.
Higher levels can cause coma and even death.
High or repeated exposure can damage the nerves causing weakness, "pins and needles." and poor coordination in arms and legs.
Ethylene Chlorohydrin can cause liver and kidney damage.
Ethylene Chlorohydrin is on the Hazardous Substance List because it is regulated by OSHA and cited by ACGIH, DOT. NIOSH, NFPA and EPA.
Breathing Ethylene Chlorohydrin can irritate the nose and throat causing coughing and wheezing.
Breathing Ethylene Chlorohydrin can irritate the lungs causing coughing and/or shortness of breath. Higher exposures may cause a build-up of fluid in the lungs
(pulmonary edema), a medical emergency, with severe shortness of breath.
Ethylene Chlorohydrin can cause nausea. vomiting and abdominal pain.
Ethylene Chlorohydrin can affect concentration and memory and can cause headache. dizziness.lightheadedness. confusion, seizures (fits) and passing out.Higher levels can cause coma and even death.
Ethylene Chlorohydrin Chronic Health Effects
The following chronic (long-term) health effects can occur at some time after exposure to Ethylene Chlorohydrin and can last for months or years:
Ethylene Chlorohydrin Cancer Hazard
There is no evidence that Ethylene Chlorohydrin causes cancer in animals. This is based on test results presently available to the New Jersey Department of Health and Senior Services from published studies.
Ethylene Chlorohydrin Reproductive Hazard
Ethylene Chlorohydrin may cause reproductive damage Handle with extreme caution.
Ethylene Chlorohydrin Other Long-Term Effects
Ethylene Chlorohydrin can irritate the lungs. Repeated exposure may cause bronchitis to develop with cough,phlegm, and/or shortness of breath.
High or repeated exposure can damage the nerves causing weakness, "pins and needles." and poor coordination in arms and legs.
Ethylene Chlorohydrin can cause liver and kidney damage.
Ethylene Chlorohydrin Mixed Exposures
Because more than light alcohol consumption can cause liver damage, drinking alcohol can increase the liver damage caused by Ethylene Chlorohydrin.
Ethylene chlorohydrin Production
ethylene chlorohydrin is produced by treating ethylene with hypochlorous acid:
CH2=CH2 + HOCl → HOCH2CH2Cl
ethylene chlorohydrin Toxicity Data With Reference
1. skn-rbt 200 mg/2H MLD
TXAPA9 Toxicology and Applied Pharmacology. 16 (1970),382.
2. eye-rbt 2 mg SEV
AJOPAA American Journal of Ophthalmology. 29 (1946),1363.
3. eye-rbt 33 mg MOD
TXAPA9 Toxicology and Applied Pharmacology. 16 (1970),382.
4. eye-rbt 9 mg/6H MOD
BUYRAI Bulletin of Parenteral Drug Association. 31 (1977),25.
5. sln-asn 74,500 μmol/L
MUREAV Mutation Research. 138 (1984),33.
6. oms-rat:lvr 12 g/L
JACTDZ Journal of the American College of Toxicology. 1 (3)(1982),37.
7. ihl-man LCLo:305 ppm/2H
JIHTAB Journal of Industrial Hygiene and Toxicology. 26 (1944),277.
8. orl-rat LD50:71 mg/kg
HYSAAV Hygiene and Sanitation: English Translation of Gigiena Sanitariya. 36 (1971),376.
9. ihl-rat LC50:290 mg/m3
HYSAAV Hygiene and Sanitation: English Translation of Gigiena Sanitariya. 26 (1971),376.
10. ipr-rat LD50:58 mg/kg
TXAPA9 Toxicology and Applied Pharmacology. 21 (1972),454.
RTECS :KK0875000
ethylene chlorohydrin is toxic with an LD50 of 89 mg/kg in rats.
Ethylene chlorohydrin Consensus Reports
NTP Carcinogenesis Studies (dermal); No Evidence: mouse, rat NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No. NTP-TR-275 ,1985. ; Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program. EPA Extremely Hazardous Substances List.
Ethylene chlorohydrin Safety Profile
A poison by ingestion, inhalation, skin contact, intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic to humans by inhalation. It can affect the nervous system, liver, spleen, and lungs. An experimental teratogen. Mutation data reported. A severe eye and mild skin irritant. Flammable liquid when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. Violent reaction with chlorosulfonic acid, ethylene diamine, sodium hydroxide. Reacts with water or steam to produce toxic and corrosive fumes. Potentially violent reaction with oxidizing materials. When heated to decomposition it emits highly toxic fumes of Cl? and phosgene. See also CHLORINATED HYDROCARBONS, ALIPHATIC.
Like most organochlorine compounds, ethylene chlorohydrin combusts to yield hydrogen chloride and phosgene.
Hazard Codes: T+,T,F
Risk Statements : 26/27/28-39/23/24/25-11
Safety Statements : 28-45-7/9-28A-36/37-16
RIDADR :UN 1135 6.1/PG 1
WGK Germany 3
Ethylene chlorohydrin Standards and Recommendations
OSHA PEL: CL 1 ppm (skin)
ACGIH TLV: CL 1 ppm (skin); Not Classifiable as a Human Carcinogen
DFG MAK: 1 ppm (3.3 mg/m2)
DOT Classification: 6.1; Label: Poison
ethylene chlorohydrin Analytical Methods
For occupational chemical analysis use NIOSH: ethylene chlorohydrin, 2513.
Ethylene chlorohydrin Specification
Other names of ethylene chlorohydrin :2-chloroethyl alcohol, ethylene chlorohydrin, 2-chloro-1-ethanol, 2-monochloroethanol,glycol chlorohydrin, 2-hydroxyethyl chloride, β-hydroxyethyl chloride, β-chloroethanol,chloroethanol,ethylchlorhydrin, δ-chloroethanol, ethylene chlorohydrin, glycol monochlorohydrin.
the following control is recommended to ethylene chlorohydrin
where possible, automatically pump liquid ethylene chlorohydrin from drums or other storage containers to process containers.good work practices can help to reduce hazardous
exposures.
the following work practices are recommended to ethylene chlorohydrin
workers whose clothing has been contaminated by ethylene chlorohydrin should change into clean clothing promptly.
contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to ethylene chlorohydrin.
eye wash fountains should be provided in the immediate work area for emergency use.
if there is the possibility of skin exposure, emergency shower facilities should be provided.
on skin contact with ethylene chlorohydrin,immediately wash or shower to remove the chemical. at the end of the workshift, wash any areas of the body that may have contacted ethylene chlorohydrin, whether or not known skin contact has occurred.
do not eat. smoke. or drink where ethylene chlorohydrin is handled, processed. or stored, since the chemical can be swallowed. wash hands carefully before eating, drinking, smoking, or using the toilet.
ethylene chlorohydrin handling and storage
prior to working with ethylene chlorohydrin you should be trained on its proper handling and storage.
ethylene chlorohydrin reacts violently with chlorosulfonic acid; ethylene diamine;sodium hydroxide and oxidizing agents(such as perchlorates. peroxides,permanganates.chlorates. nitrates,chlorine. bromine and fluorine).
ethylene chlorohydrin is not compatible with strong bases (such as potassium hydroxide); strong acids (such as hydrochloric, sulfuric and nitric); and alkaline metals.
store in tightly closed containers in a cool. well-ventilated area away from water and steam as corrosive gases are produced.
sources of ignition. such as smoking and open flames, are prohibited where ethylene chlorohydrin is used, handled. or stored in a manner that could create a potential fire or explosion hazard.
Ethylene chlorohydrin images
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