2-chloroethanol_Volumetric properties of amino acids in aqueous solutions of chloroethanol

The densities of glycine, L-alanine and L-serine in aqueous chloroethanol solutions of different mass fractions were determined using a precision mathematical densitometer, and the expressed molar volume, limiting paramolar volume of amino acids in aqueous chloroethanol solutions were calculated. The migrating partial molar volume, theoretical hydration number and volumetric action coefficient demonstrated that the migrating partial molar volumes of the three amino acids in aqueous chloroethanol solutions were positive and increased with the increase of chloroethanol concentration. The contribution of amino acid measurement chains to the migrating bi-molar volume was closely related to the nature of side chains. The theoretical hydration numbers of all three amino acids in aqueous chloroethanol solutions decreased with increasing chloroethanol concentration in solution. The intermolecular interactions between glycine and chloroethanol were mainly in the 1:1 and 1:2 forms, and the intermolecular interactions between L-alanine and L-serine and chloroethanol were mainly in the 1:1 form.