Ethylene chlorohydrin was found to be unstable on activated charcoal

Sampling of epichlorohydrin and ethylene chlorohydrin in workroom air using Amberlite XAD-7 resin

Activated charcoal, Amberlite XAD-2 and Amberlite XAD-7 were evaluated for the adsorption of epichlorohydrin and ethylene chlorohydrin from air followed by desorption with solvent. Ethylene chlorohydrin was found to be unstable on activated charcoal in the presence of carbon disulfide. Recoveries from XAD-2 were low, and XAD-7 was found to be the best adsorbent for the sampling of these compounds from air.

Toxicity of ethylene chlorohydrin I: Acute toxicity studies

Abstract The LD 50 of ethylene chlorohydrin was evaluated in mice, rats, rabbits, and guinea pigs, and the range of values was found to fall between 64 and 98 mg./kg. The mean time of death from vapors of the compound was calculated to be 13.3 min. when mice were used as the test animals. Dermal tests in rabbits produced no significant irritant response even when applied undiluted; but when the compound was injected intradermally or instilled into the eye, it was extremely irritating. Ethylene chlorohydrin was found to be cytotoxic in cell culture and to have an inhibitory effect upon cell growth in cultures. Since plastic devices are being ethylene oxide-sterilized and since ethylene chlorohydrin may form as a reaction product, it is necessary to be aware of the toxic potentials of this compound